Quantitative Analysis of Limonin in Grapefruit Juice Using an Enzyme-Linked Immunoassay: Interlaboratory Study
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چکیده
منابع مشابه
Pharmacokinetic analysis of felodipine-grapefruit juice interaction based on an irreversible enzyme inhibition model.
UNLABELLED Aims Ingestion of grapefruit juice (GFJ) alters the pharmacokinetics of various orally administered drugs. Quantitative evaluation of this GFJ-drug interaction is required for the proper clinical management of patients. Methods Using felodipine as a model drug, we constructed a pharmacokinetic model based on irreversible inhibition of intestinal cytochrome P450 3A4 (CYP3A4) by GFJ. W...
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The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol. Subsequent investigations showed that grapefruit juice acted by reducing presystemic felodipine ...
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ژورنال
عنوان ژورنال: Journal of AOAC INTERNATIONAL
سال: 1991
ISSN: 0004-5756
DOI: 10.1093/jaoac/74.3.513